Subject. This article explores uncertainties in economic development and regional differentiation in terms of development. Objectives. The article aims to study the issues of cooperation between the Siberian regions as part of a comprehensive project. Methods. For the study, I used a statistical analysis. Conclusions. Consolidating inter-regional cooperation strengthens systemic and economic ties, boosts investment and quality infrastructure development. Cooperation also plays a key role in the system and spatial placement of productive forces.
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