Importance The article deals with the interregional innovation economic integration, regional spatial development processes, rational allocation of productive forces and the strengthening of the role of regional economies. The subject of the study is the directions of innovative interregional integration of socio-economic systems in order to create a single economic space of the federal district and the country as a whole. Objectives The goal of the paper is to identify areas that would most objectively identify the effective economic integration of regions for innovation. Methods We used economic-mathematical methods of investigation, as well as a graphical analysis. Results We have identified nine indicators of innovation and economic development of the regions and assessed them, as well as the degree of their influence on the processes of regional economic integration. We graphed the magnitude and built the graphs of equations of regression and the borders of a confidence interval, the regression equations and observed values of the analyzed indicators. In addition, we have completed binary clustering of regions of the Russian Federation on innovative activity. We marked the trend towards localization of markets. Conclusions and Relevance We concluded that the Central Federal District has a relatively high capacity and efficiency of interregional economic integration of innovative socio-economic systems of the constituent entities of the Federation, as well as the substantial margin of unused resources, despite the fact that the cost for technology, marketing and organizational innovation is lagging behind. We offer the directions of interregional integration, which will increase the capacity of innovation impact.
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