Subject. This article discusses the issues of ensuring the economic efficiency of regional socio-economic systems. Objectives. The article aims to determine the optimal form of cooperation between the participants of the Yenisey Siberia Comprehensive Investment Project. Methods. For the study, I used a statistical analysis and the interaction theory concepts. Results. The article proposes an original approach to the integration of regional economic systems, which helps identify priority areas of cooperation. Conclusions. Monitoring of the interaction of the regions participating in the Yenisey Siberia project is of paramount importance. The results of the study can be taken into account by regional authorities when forming strategies for the socio-economic development of regions.
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