Importance Escalating economic discrepancies, sanction policies, unpredictable development of economic integration call us to study principles of economic cooperation among the Russian regions. The principles are intended to ensure the economic security not only regionally, but also nationally, bridging the gap among the regions from perspectives of their socio-economic development. Objectives The research outlines theoretical principles and methodological constructs of the regional economic security in the time of integration processes. Methods The research involves principles of a systems approach, logic techniques and methods of mathematical modeling in economics. Results The article provides the theoretical rationale for basic constituents of the regional economic security and examines the content of definitions economic security, regional economic security. We hypothesize about the basic principle for identifying economic security factors at the regional level. The article substantiates the importance of administrative resources within the total factors of regional economic security. Conclusions and Relevance We suggest using Gross Regional Product per capita as the basic monitoring tool and holistic indicator based on formalized indicators of regional economic security.
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