Importance The article discusses the aspects of increasing the innovative activity of regions and industry clusters. Objectives The article purports to show how the strategy of enhancing the competitiveness of the economy of the Russian Federation is implemented in a key cluster of the country's development, namely in the regions of the Central Federal District. Methods We used analytical, forecasting and expert methods, as well as a mathematical modeling technique for adjusting the cluster estimates. Results The article says there is a need for certain activities to make network innovation structures in the regions on the basis of a cluster approach, include certain measures to support the development of national and regional high-priority clusters in programs of regional development, attract scientific and educational centers to study the world experience of cluster development, and train professionals for work under the conditions of cluster formation of the economy. Conclusions and Relevance Formation of clustered entities should be based on strategic decisions made in relation to profit control associated with the stages of social reproduction. The formation and development of clusters lead to many integral advantages at the region and country levels.
Keywords: regional clusters, production system, business competitiveness, economic policy, simulation, development
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